Humoral immune response to infective larval antigen in Brugia malayi infected Mastomys natalensis.
Identifieur interne : 00D538 ( Main/Exploration ); précédent : 00D537; suivant : 00D539Humoral immune response to infective larval antigen in Brugia malayi infected Mastomys natalensis.
Auteurs : K. Cheirmaraj [Inde] ; B C HarinathSource :
- Acta tropica [ 0001-706X ] ; 1991.
Descripteurs français
- KwdFr :
- MESH :
- biosynthèse : Anticorps antihelminthe, Immunoglobuline G, Immunoglobuline M.
- immunologie : Antigènes d'helminthe, Brugia, Filariose lymphatique, Larve.
- Animaux, Muridae, Mâle, Test ELISA.
English descriptors
- KwdEn :
- MESH :
- chemical , biosynthesis : Antibodies, Helminth, Immunoglobulin G, Immunoglobulin M.
- chemical , immunology : Antigens, Helminth.
- immunology : Brugia, Elephantiasis, Filarial, Larva.
- Animals, Enzyme-Linked Immunosorbent Assay, Male, Muridae.
Abstract
The sequential changes in the humoral immune response against infective larval antigens during the course of Brugia malayi infection in Mastomys natalensis have been studied using enzyme linked immunosorbent assay. IgM antibody against B. malayi infective larval excretory secretory (ES) antigen was detected in the peripheral circulation within a week of infection, whereas IgM antibody against B. malayi infective larval somatic antigen and IgG antibody against both somatic and ES antigens were detected on day 20 post-inoculation. Thereafter, the antibody levels showed a steady increase until day 150. A gradual decrease of IgM antibody level was observed upto day 360, whereas IgG antibody level was decreased upto day 250 and then maintained almost the same level upto day 360. Wuchereria bancrofti cross reactive antigen as well as B. malayi infective larval ES antigen were detected in blood circulation on day 20, the level increased upto day 150 and then remained almost the same upto day 360 with slight variations. Studies of antigen and antibody levels in microfilaraemic and amicrofilaraemic animals show that there is no significant difference in antibody level whereas elevated antigen titre was observed in active infection with microfilaraemia.
PubMed: 1674404
Affiliations:
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Cheirmaraj</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, Mahatma Gandhi Institute of Medical Sciences, Sevagram, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Biochemistry, Mahatma Gandhi Institute of Medical Sciences, Sevagram</wicri:regionArea><wicri:noRegion>Sevagram</wicri:noRegion></affiliation></author><author><name sortKey="Harinath, B C" sort="Harinath, B C" uniqKey="Harinath B" first="B C" last="Harinath">B C Harinath</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1991">1991</date><idno type="RBID">pubmed:1674404</idno><idno type="pmid">1674404</idno><idno type="wicri:Area/PubMed/Corpus">005C05</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">005C05</idno><idno type="wicri:Area/PubMed/Curation">005C05</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">005C05</idno><idno type="wicri:Area/PubMed/Checkpoint">005C05</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">005C05</idno><idno type="wicri:Area/Ncbi/Merge">002269</idno><idno type="wicri:Area/Ncbi/Curation">002269</idno><idno type="wicri:Area/Ncbi/Checkpoint">002269</idno><idno type="wicri:doubleKey">0001-706X:1991:Cheirmaraj K:humoral:immune:response</idno><idno type="wicri:Area/Main/Merge">00E070</idno><idno type="wicri:Area/Main/Curation">00D538</idno><idno type="wicri:Area/Main/Exploration">00D538</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Humoral immune response to infective larval antigen in Brugia malayi infected Mastomys natalensis.</title><author><name sortKey="Cheirmaraj, K" sort="Cheirmaraj, K" uniqKey="Cheirmaraj K" first="K" last="Cheirmaraj">K. Cheirmaraj</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, Mahatma Gandhi Institute of Medical Sciences, Sevagram, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Biochemistry, Mahatma Gandhi Institute of Medical Sciences, Sevagram</wicri:regionArea><wicri:noRegion>Sevagram</wicri:noRegion></affiliation></author><author><name sortKey="Harinath, B C" sort="Harinath, B C" uniqKey="Harinath B" first="B C" last="Harinath">B C Harinath</name></author></analytic><series><title level="j">Acta tropica</title><idno type="ISSN">0001-706X</idno><imprint><date when="1991" type="published">1991</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Helminth (biosynthesis)</term><term>Antigens, Helminth (immunology)</term><term>Brugia (immunology)</term><term>Elephantiasis, Filarial (immunology)</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Immunoglobulin G (biosynthesis)</term><term>Immunoglobulin M (biosynthesis)</term><term>Larva (immunology)</term><term>Male</term><term>Muridae</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antihelminthe (biosynthèse)</term><term>Antigènes d'helminthe (immunologie)</term><term>Brugia (immunologie)</term><term>Filariose lymphatique (immunologie)</term><term>Immunoglobuline G (biosynthèse)</term><term>Immunoglobuline M (biosynthèse)</term><term>Larve (immunologie)</term><term>Muridae</term><term>Mâle</term><term>Test ELISA</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Antibodies, Helminth</term><term>Immunoglobulin G</term><term>Immunoglobulin M</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Helminth</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Anticorps antihelminthe</term><term>Immunoglobuline G</term><term>Immunoglobuline M</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes d'helminthe</term><term>Brugia</term><term>Filariose lymphatique</term><term>Larve</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Brugia</term><term>Elephantiasis, Filarial</term><term>Larva</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Male</term><term>Muridae</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Muridae</term><term>Mâle</term><term>Test ELISA</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The sequential changes in the humoral immune response against infective larval antigens during the course of Brugia malayi infection in Mastomys natalensis have been studied using enzyme linked immunosorbent assay. IgM antibody against B. malayi infective larval excretory secretory (ES) antigen was detected in the peripheral circulation within a week of infection, whereas IgM antibody against B. malayi infective larval somatic antigen and IgG antibody against both somatic and ES antigens were detected on day 20 post-inoculation. Thereafter, the antibody levels showed a steady increase until day 150. A gradual decrease of IgM antibody level was observed upto day 360, whereas IgG antibody level was decreased upto day 250 and then maintained almost the same level upto day 360. Wuchereria bancrofti cross reactive antigen as well as B. malayi infective larval ES antigen were detected in blood circulation on day 20, the level increased upto day 150 and then remained almost the same upto day 360 with slight variations. Studies of antigen and antibody levels in microfilaraemic and amicrofilaraemic animals show that there is no significant difference in antibody level whereas elevated antigen titre was observed in active infection with microfilaraemia.</div></front></TEI><affiliations><list><country><li>Inde</li></country></list><tree><noCountry><name sortKey="Harinath, B C" sort="Harinath, B C" uniqKey="Harinath B" first="B C" last="Harinath">B C Harinath</name></noCountry><country name="Inde"><noRegion><name sortKey="Cheirmaraj, K" sort="Cheirmaraj, K" uniqKey="Cheirmaraj K" first="K" last="Cheirmaraj">K. Cheirmaraj</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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